Selected Recent Publications

2018

An Abeis procera - Derived tetracyclic triterpene containing a steroid-like core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni

Whiteland, H., Chakroborty, A., Forde-Thomas, J., Crusco, A., Cookson, A., Hollinshead, J., Fenn, C., Bartholomew, B., Holdsworth, P. A., Fisher, M., Nash, R. J. & Hoffmann, K. 2018 In : International Journal for Parasitology: Drugs and Drug Resistance

Article DOI:  10.1016/j.ijpddr.2018.10.009

 

Antibody Responses to Schistosoma mansoni Schistosomula Antigens

Egesa M., Lubyayi L, Jones F, van Diepen A, Chalmers I, Tukahebwa E, Bagaya B, Hokke C, Hoffmann K, Dunne D, Elliott A,8, Yazdanbakhsh M, Wilson S, Cose S.  21 Sep 2018 In : Parasite Immunology. e12591.

Article DOI: 10.1111/pim.12591

 

S. mansoni Schistosomula Antigens Induce Th1/Proinflammatory Cytokine Responses

Egesa, M., Lubyayi, L., Tukahebwa, E. M., Bagaya, B. S., Chalmers, I., Wilson, S., Hokke, C. H., Hoffmann, K., Dunne, D. W., Yazdanbakhsh, M., Labuda, L. A. & Cose, S. 21 Sep 2018 In : Parasite Immunology. e12592

Article DOI: 10.1111/pim.12592

 

The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulation transcription, translation and stem cell activities

Geyer, K., Munshi, S. E., Vickers, M., Squance, M., Wilkinson, T., Berrar, D., Chaparro, C., Swain, M. & Hoffmann, K. 01 Aug 2018 In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 2, p. 213-222 10 p.

Article DOI: 10.1016/j.ijpddr.2018.03.006

 

Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni

Geyer, K., Munshi, S. E., Whiteland, H., Fernandez-Fuentes, N., Phillips, D. & Hoffmann, K. 28 Jun 2018 In : PLOS Pathogens.

Article DOI: 10.1371/journal.ppat.1007107

 

Detection of Galba truncatula, Fasciola hepatica and Calicophoron daubneyi environmental DNA within water sources on pasture land, a future tool for fluke control?

Jones, R., Brophy, P., Davis, C., Davies, T., Emberson, H., Rees Stevens, P. & Williams, H. 08 Jun 2018 In : Parasites & Vectors. 11, 342

Article DOI: 10.1186/s13071-018-2928-z

 

Purification of native Sigma Class Glutathione Transferase from Fasciola hepatica

Duncan, J., Cutress, D., Morphew, R. & Brophy, P. 01 Jun 2018 In : Molecular and Biochemical Parasitology. 222, p. 45-50 6 p.

Article DOI: 10.1016/j.molbiopara.2018.04.006

 

Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues

Crusco, A., Bordoni, C., Chakroborty, A., Whatley, K. C. L., Whiteland, H., Westwell, A. D. & Hoffmann, K. 25 May 2018 In : European Journal of Medicinal Chemistry. 152, p. 87-100

Article DOI: 10.1016/j.ejmech.2018.04.032

 

Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni

Roquis, D., Taudt, A., Geyer, K., Padalino, G., Hoffmann, K., Holroyd, N., Berriman, M., Allaga, B., Chaparro, C., Grunau, C. & de Carvalho Augusto, R. 21 May 2018 In : PLOS Pathogens. 14, 5, 26 p., 1007066

Article DOI: 10.1371/journal.ppat.1007066

 

2017

Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles

Egesa, M., Hoffmann, K., Hokke, C. H., Yazdanbakhsh, M. & Cose, S. 01 Dec 2017 In : Trends in Parasitology. 1671, 4 p.

Article DOI: 10.1016/j.pt.2017.07.007

 

Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense

Nur-e-Alam, M, Yousaf, M, Ahmed, S, Al-Sheddi, ES, Shah, I, Fazakerley, D, Bari, A, Ghabbour, HA, Threadgill, MD, Whatley, K, Hoffmann, K & Al-Rehaily, AJ 2017, ' Journal of Natural Products.

Article DOI: 10.1021/acs.jnatprod.7b00188

 

Saprotrophic proteomes of biotypes of the witches’ broom pathogen Moniliophthora perniciosa

Pierre, S, Griffith, G, Morphew, R, Mur, L & Scott, I 2017, Fungal Biology. Article

DOI: 10.1016/j.funbio.2017.05.004

 

The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni

Geyer, K, Niazi, U, Duval, D, Cosseau, C, Tomlinson, C, Chalmers, I, Swain, M, Cutress, D, Bickham-Wright, U, Munshi, SE, Grunau, C, Yoshino, TP & Hoffmann, K 2017, PLoS Neglected Tropical Diseases, vol 11, no. 5, e0005246.

Article DOI: 10.1371/journal.pntd.0005246

 

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Adema, CM, Hillier, LW, Jones, CS, Loker, ES, Knight, M, Minx, P, Oliveira, G, Raghavan, N, Shedlock, A, do Amaral, LR, Arican-Goktas, HD, Assis, JG, Baba, EH, Baron, OL, Bayne, CJ, Bickham-Wright, U, Biggar, KK, Blouin, M, Bonning, BC, Botka, C, Bridger, JM, Buckley, KM, Buddenborg, SK, Lima Caldeira, R, Carleton, J, Carvalho, OS, Castillo, MG, Chalmers, IW, Christensens, M, Clifton, S, Cosseau, C, Coustau, C, Cripps, RM, Cuesta-Astroz, Y, Cummins, SF, Di Stephano, L, Dinguirard, N, Duval, D, Emrich, S, Feschotte, C, Feyereisen, R, Fitzgerald, P, Fronick, C, Fulton, L, Galinier, R, Gava, SG, Geusz, M, Geyer, KK, Giraldo-Calderón, GI, de Souza Gomes, M, Gordy, MA, Gourbal, B, Grunau, C, Hanington, PC, Hoffmann, KF, Hughes, D, Humphries, J, Jackson, DJ, Jannotti-Passos, LK, De Jesus Jeremias, W, Jobling, S, Kamel, B, Kapusta, A, Kaur, S, Koene, JM, Kohn, AB, Lawson, D, Lawton, SP, Liang, D, Limpanont, Y, Liu, S, Lockyer, AE, Lovato, TL, Ludolf, F, Magrini, V, Mcmanus, DP, Medina, M, Misra, M, Mitta, G, Mkoji, GM, Montague, MJ, Montelongo, C, Moroz, LL, Munoz-Torres, MC, Niazi, U, Noble, LR, Oliveira, FS, Pais, FS, Papenfuss, AT, Peace, R, Pena, JJ, Pila, EA, Quelais, T, Raney, BJ, Rast, JP, Rollinson, D, Rosse, IC, Rotgans, B, Routledge, EJ, Ryan, KM, Scholte, LLS, Storey, KB, Swain, M, Tennessen, JA, Tomlinson, C, Trujillo, DL, Volpi, EV, Walker, AJ, Wang, T, Wannaporn, I, Warren, WC, Wu, X-J, Yoshino, TP, Yusuf, M, Zhang, S-M, Zhao, M & Wilson, RK 2017, Nature Communications, vol 8, 15451 (2017), pp. 15451.

Article DOI: 10.1038/ncomms15451

 

The prevalence and development of digenean parasites within their intermediate snail host, Galba truncatula, in a geographic area where the presence of Calicophoron daubneyi has recently been confirmed

Jones, R, Williams, H, Dalesman, S, Sinmidele, A, Thomas, RK & Brophy, P 2017, Veterinary Parasitology.

Article DOI: 10.1016/j.vetpar.2017.03.021

 

Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial 

Garcia-Perez, I, Posma, JM, Gibson, R, Chambers, ES, Hanson, TH, Vestergaard, H, Hansen, T, Beckmann, M, Pedersen, O, Elliott, P, Stamler, J, Nicholson, JK, Draper, J, Mathers, JC, Holmes, E & Frost, G 2017, Lancet Diabetes and Endocrinology, vol 5, no. 3, pp. 184-195. Article DOI: 10.1016/S2213-8587(16)30419-3

2016

(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

Cosseau, C, Wolkenhauer, O, Padalino, G, Geyer, K, Hoffmann, K & Grunau, C 2016, ' Trends in Parasitology.

Article DOI: 10.1016/j.pt.2016.12.002

 

Upgrading short read animal genome assemblies to chromosome level using comparative genomics and a universal probe set

Damas, J, O'connor, R, Farré, M, Lenis, V, Martell, H, Mandawala, A, Fowler, K, Joseph, S, Swain, M, Griffin, D & Larkin, DM 2016, Genome Research, vol 27, pp. 875-884.

Article DOI: 10.1101/gr.213660.116

 

Challenges and priorities for modelling livestock health and pathogens in the context of climate change

Özkan, Ş, Vitali, A, Lacetera, N, Amon, B, Bannink, A, Bartley, DJ, Blanco-penedo, I, De Haas, Y, Dufrasne, I, Elliott, J, Eory, V, Fox, NJ, Garnsworthy, PC, Gengler, N, Hammami, H, Kyriazakis, I, Leclère, D, Lessire, F, Macleod, M, Robinson, TP, Ruete, A, Sandars, DL, Shrestha, S, Stott, AW, Twardy, S, Vanrobays, M-L, Ahmadi, BV, Weindl, I, Wheelhouse, N, Williams, AG, Williams, HW, Wilson, AJ, Østergaard, S & Kipling, RP 2016, Environmental Research, vol 151, pp. 130-144.

Article DOI: 10.1016/j.envres.2016.07.033

 

MetaPred2CS: a sequence-based meta-predictor for protein-protein interactions of prokaryotic two-component system proteins

Kara, A, Vickers, M, Swain, M, Whitworth, D & Fernandez-Fuentes, N 2016, Bioinformatics, vol 32, no. 21, pp. 3339-3341.

Article DOI: 10.1093/bioinformatics/btw403

 

Rumen fluke Calicophoron daubneyi on Welsh farms: Prevalence, risk factors, and observations on co-infection with Fasciola hepatica

Jones, R, Brophy, P, Mitchell, ES & Williams, H 2016 Parasitology, pp. 237-247.

Article DOI: 10.1017/S0031182016001797

 

MultiGrain/MAPPER: A distributed multiscale computing approach to modeling and simulating gene regulation networks

Mizeranschi, AE, Swain, MT, Scona, R, Fazilleau, Q, Bosak, B, Piontek, T, Kopta, P, Thompson, P & Dubitzky, W 2016 Future Generation Computer Systems, vol 63, pp. 1-14.

Article DOI: 10.1016/j.future.2016.04.002

Antelope Diseases - the Good, the Bad and the Ugly. in Antelope Conservation: From Diagnosis to Action.

Kock, R, Chardonnet, P & Risley, C 2016, Conservation Science and Practice, Wiley, pp. 108-135.

 

Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola Species

Morphew, R, Wilkinson, T, MacKintosh, N, Jahndel, V, Paterson, S, McVeigh, P, Abbas Abidi, SM, Saifullah, K, Raman, M, Ravikumar , G, LaCourse, EJ, Maule, AG & Brophy, P 2016, Journal of Proteome Research, vol 15, no. 9, pp. 3308-3321.

Article DOI: 10.1021/acs.jproteome.6b00331

 

DISMISS: MeDIP-seq: High-throughput sequencing

Niazi, U, Geyer, K, Vickers, M, Hoffmann, K & Swain, M, , 2016, Software, OMICtools.

 

DISMISS: detection of stranded methylation in MeDIP-Seq data

Niazi, U, Geyer, KK, Vickers, MJ, Hoffmann, K & Swain, M 2016, BMC Bioinformatics, vol 17, 295.

Article DOI: 10.1186/s12859-016-1158-7

 

InteractoMIX: a suite of computational tools to exploit interactomes in biological and clinical research

Poglayen, D, Marín-López, MA, Bonet, J, Fornes, O, Garcia-Garcia, J, Planas-Iglesias, J, Segura, J, Oliva, B & Fernandez-Fuentes, N 2016, Biochemical Society Transactions, vol 44, no. 3, pp. 917-924. Article DOI: 10.1042/BST20150001

 

The effects of PPO activity on the proteome of ingested red clover and implications for improving the nutrition of grazing cattle 

Hart, E, Onime, LA, Davies, T, Morphew, R & Kingston-Smith, A 2016, Journal of Proteomics, vol 141, pp. 67-76.

Article DOI: 10.1016/j.jprot.2016.04.023

 

Calmodulin disruption impacts growth and motility in juvenile liver fluke

McCammick, E, McVeigh, P, McCusker, P, Timson, D, Morphew, R, Brophy, P, Marks, N, Mousley, A & Maule, A 2016, ' Parasites & Vectors, vol 9, 46.

Article DOI: 10.1186/s13071-016-1324-9