Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation

Gilda Padalino, Nelly El-Sakkary, Lawrence J. Liu, Chenxi Liu, Danielle S. G. Harte, Rachel E. Barnes, Edward Sayers, Josephine Forde-Thomas, Helen Whiteland, Marcella Bassetto, Salvatore Ferla, George Johnson, Arwyn T. Jones, Conor R. Caffrey, Iain Chalmers, Andrea Brancale, Karl F. Hoffmann (2021). European Journal of Medicinal Chemistry, Vol. 226, 113823, 15 December 2021.

Article DOI: https://doi.org/10.1016/j.ejmech.2021.113823

Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout Schistosoma mansoni Infection

Lauren M Webb, Alexander T Phythian-Adams, Alice H Costain, Sheila L Brown, Rachel J Lundie, Josephine Forde-Thomas, Peter C Cook, Lucy H Jackson-Jones, Angela K Marley, Hermelijn H Smits, Karl F Hoffmann, Elia D Tait Wojno, Andrew S MacDonald, 30 August 2021, In : Immunohorizons, ISSN 2573-7732

Article DOI: https://doi.org/10.4049/immunohorizons.2100071

Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni

Frederick A. Partridge, Carole J.R. Bataille, Ruth Forman, Amy E. Marriott, Josephine Forde-Thomas, Cécile Häberli, Ria L. Dinsdale, James D.B. O’Sullivan, Nicky J. Willis, Graham M. Wynne, Helen Whiteland, John Archer, Andrew Steven, Jennifer Keiser, Joseph D. Turner, Karl F. Hoffmann, Mark J. Taylor, Kathryn J. Else*, Angela J. Russell*, and David B. Sattelle. ACS Infect. Dis. 2021, 7, 5, 1260–1274, April 2, 2021.

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Modulation of Rumen Microbes Through Extracellular Vesicle Released by the Rumen Fluke Calicophoron daubneyi. 

Allen Nathan R., Taylor-Mew Aspen R., Wilkinson Toby J., Huws Sharon, Phillips Helen, Morphew Russell M., Brophy Peter M. Front. Cell. Infect. Microbiol., 20 April 2021.

Article DOI: 10.3389/fcimb.2021.661830

Evaluation of two Fasciola hepatica faecal egg counting protocols in sheep and cattle. 

Claire Reigate, Hefin W.Williams, Matthew J.Denwood, Russell M.Morphew, Eurion R.Thomas, Peter M.Brophy. Veterinary Parasitology, Vol. 294, June 2021, 109435.

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Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni.

Partridge FA, Bataille CJR, Forman R, Marriott AE, Forde-Thomas J, Häberli C, Dinsdale RL, O’Sullivan JDB, Willis NJ, Wynne GM, Whiteland H, Archer J, Steven A, Keiser J, Turner JD, Hoffmann KF, Taylor MJ, Else KJ, Russell AJ, Sattelle DB (2021).

Article DOI: 10.1021/acsinfecdis.1c00025

Characterization of class II fumarase from Schistosoma mansoni provides the molecular basis for selective inhibition.

Cardoso IA, de Souza AKL, Burgess AMG, Chalmers IW, Hoffmann KF, Nonato MC.Int J Biol Macromol. 2021 Apr 1;175:406-421.

Article DOI: 10.1016/j.ijbiomac.2021.01.180

Identifying and validating the presence of Guanine Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni.

Holly M. Craven, Riccardo Bonsignore, Vasilis Lenis,Nicolo Santi, Daniel Berrar, Martin Swain, Helen Whiteland, Angela Casini, Karl F. Hoffmann (2021). PLOS Neglected Tropical Diseases, February 18, 2021

Article DOI: https://doi.org/10.1371/journal.pntd.0008770

In vitro screening as an anthelmintic discovery pipeline for Calicophoron daubneyi: nutritive media and rumen environment-based approaches.

Huson, K.M., Morphew, R.M., Winters, A. et al. (2021).

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The soluble glutathione transferase superfamily: Role of Mu class in Triclabendazole sulphoxide challenge in Fasciola hepatica

Stuart, R., Zwaanswijk, S., MacKintosh, N., Wititkornkul, B., Brophy, P. & Morphew, R., In: Parasitol Res (2021).

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Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities.

Padalino G, Chalmers IW, Brancale A, Hoffmann KF.Wellcome Open Res. 2020 Nov 13;5:169.

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Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function.

Samirah Perally, Kathrin K. Geyer, Priscila S.G. Farani, Iain W. Chalmers, Narcis Fernandez-Fuentes, Daniel R. Maskell, Benjamin J. Hulme, Josephine Forde-Thomas, Dylan Phillips, Leonardo P. Farias, James J. Collins, Karl F. Hoffmann, 28 November 2020, In : International Journal for Parasitology, ISSN 0020-7519

Article DOI: https://doi.org/10.1016/j.ijpara.2020.09.004

RNA interference dynamics in juvenile Fasciola hepatica are altered during in vitro growth and development

McCosker, P., Hussain, W., McVeigh, P., McCammick, E., Clarke, N., McKay, F., Robb, E., Brophy, P., Timson, D., Mousley, A., Marks, N. & Maule, A., 01 Dec 2020, In : International Journal for Parasitology: Drugs and Drug Resistance, vol. 14, p. 46-55 10 p.

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Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal

Helen Whiteland, Alessandra Crusco, Lisa W. Bloemberg, Jamie Tibble-Howlings, Josephine Forde-Thomas, Avril Coghlan, Patrick J. Murphy, Karl F. Hoffmann, 19 October 2020, In : PLOS Neglected Tropical Diseases, 14(10): e0008630.

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Rapid detection of Galba truncatula in water sources on pasture-land using loop-mediated isothermal amplification for control of trematode infections

Davis, C., Tyson, F., Cutress, D., Davies, E., Jones, D., Brophy, P., Prescott, A., Rose, M., Williams, M., Williams, H. & Jones, R., 30 Sep 2020, In : Parasites & Vectors, vol. 13, 496, 11 p.

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Large-scale RNAi screening uncovers therapeutic targets in the parasite Schistosoma mansoni

Jipeng Wang,  Carlos Paz,  Gilda Padalino,  Avril Coghlan,  Zhigang Lu, Irina Gradinaru, Julie N. R. Collins,  Matthew Berriman, Karl F. Hoffmann,  James J. Collins III, 25 Sep 2020, In : Science, vol. 369, Issue 6511, pp. 1649-1653.

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Helminth extracellular vesicles: Great balls of wonder

Hoffmann, KF, Hokke, CH, Loukas, A & Buck, AH 2020, In : International Journal for Parasitology, vol. 50, no. 9, pp. 621-622.

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Evidence of sequestration of triclabendazole and associated metabolites by extracellular vesicles of Fasciola hepatica

Davis, C., Winters, A., Milic, I., Devitt, A., Cookson, A., Brophy, P. & Morphew, R., 10 Aug 2020, In : Scientific Reports, vol. 10, 11 p., 13445.

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The soluble glutathione transferase superfamily: Role of Mu class in Triclabendazole sulphoxide challenge in Fasciola hepatica

Stuart, R., Zwaanswijk, S., MacKintosh, N., Wititkornkul, B., Brophy, P. & Morphew, R., , In : Parasitology Research (Jan 2021).

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Pilot Evaluation of Two Fasciola hepatica Biomarkers for Supporting Triclabendazole (TCBZ) Efficacy Diagnostics

Collett, C., Morphew, R., Timson, D., Phillips, H. & Brophy, P., 30 Jul 2020, In : Molecules. 25, 15, 3477.

Article DOI: https://doi.org/10.3390/molecules25153477

Novel Equine Faecal Egg Diagnostics: Validation of the FECPAKG2

Tyson, F., Dalesman, S., Brophy, P. & Morphew, R., 23 Jul 2020, In : Animals. 10, 8, 10 p., 1254.

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DC-SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte-derived dendritic cells

Kuipers, ME, Nolte-‘t Hoen, ENM, van der Ham, AJ, Ozir-Fazalalikhan, A, Nguyen, DL, de Korne, CM, Koning, RI, Tomes, JJ, Hoffmann, KF, Smits, HH & Hokke, CH

2020 Journal of Extracellular Vesicles, vol. 9, no. 1, 1753420.

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Predatory Organisms with Untapped Biosynthetic Potential: Descriptions of Novel Corallococcus Species C. aberystwythensis sp. nov., C. carmarthensis sp. nov., C. exercitus sp. nov., C. interemptor sp. nov., C. llansteffanensis sp. nov., C. praedator sp. nov., C. sicarius sp. nov., and C. terminator sp. nov

Livingstone, PG, Ingleby, O, Girdwood, S, Cookson, AR, Morphew, RM & Whitworth, DE.  2020 Applied and Environmental Microbiology, vol. 86, no. 2, e01931-19.

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The Synthesis and Glycosidase Inhibitory Activity of Analogues of Tiruchanduramine

Murphy, Patrick & Ashworth, Zackary & Bartholomew, Barbara & Evans, Daniel & Forde-Thomas, Josephine & Hoffmann, Karl & Murdoch, Reece & Nash, Robert & Sharp, Hazel & Whiteland, Helen. January 2020. HeteroCycles, vol. 100, no. 4, pp 609-621.

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The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets.

Whatley KCL, Padalino G, Whiteland H, Geyer KK, Hulme BJ, Chalmers IW, Forde-Thomas J, Ferla S, Brancale A, Hoffmann KF. In: PLoS Negl Trop Dis. 2019 Nov 15;13(11):e0007693.

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Antischistosomal Properties of Sclareol and Its Heck-Coupled Derivatives: Design, Synthesis, Biological Evaluation and Untargeted Metabolomics

Crusco, A, Whiteland, H, Baptista, R, Forde-Thomas, JE, Beckmann, M, Mur, LAJ, Nash, RJ, Westwell, AD & Hoffmann, KF P. 2019, In ACS Infectious Diseases.

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Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

Wannaporn, I, Mann, V, Karinshak, S, Coghlan, A, Rinaldi, G, Sankaranarayanan, G, Chaidee, A, Tanno, T, Kumkhaek, C, Prangtaworn, P, Mentink-Kane, MM, Cochran, CJ, Driguez, P, Holroyd, N, Tracey, A, Rodpai, R, Everts, B, Hokke, CH, Hoffmann, K, Berriman, M & Brindley, PJ 2019, ‘ eLife, vol. 8, e41337.

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Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity

Farias, LP, Chalmers, IW, Perally, S, Rofatto, HK, Jackson, CJ, Brown, M, Khouri, MI, Barbosa, MMF, Hensbergen, PJ, Hokke, CH, Leite, LCC & Hoffmann, KF 2019 International Journal for Parasitology.

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The anti-mycobacterial activity of a diterpenoid-like molecule operates through nitrogen and amino acid starvation

Crusco, A, Alves Baptista, R, Bhowmick, S, Beckmann, M, Mur, L, Westwell, AD & Hoffmann, K 2019, ‘ Frontiers in Microbiology, vol. 10, 01444

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The importance of extracellular vesicle purification for downstream analysis: A comparison of differential centrifugation and size exclusion chromatography for helminth pathogens.

Davis CN, Phillips H, Tomes JJ, Swain MT, Wilkinson TJ, Brophy PM, Morphew, RM. In: PLoS Negl Trop Dis. 2019 Feb 27;13(2):e0007191

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Smell of Infection: a novel, non-invasive method for detection of fish excretory- secretory proteins.

Pawluk, R. J., Stuart, R., de Leaniz, C. G., Cable, J., Morphew, R. M., Brophy, P. M. and Consuegra S. 2019 In: Journal of Proteome Research.

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Polyomic tools for an emerging livestock parasite, the rumen fluke Calicophoron daubneyi; identifying shifts in rumen functionality

Huson, K. M., Morphew, R., Allen, N., Hegarty, M., Worgan, H., Girdwood, S., Jones, E. L., Phillips, H., Vickers, M., Swain, M., Smith, D., Kingston-Smith, A. & Brophy, P. 2018 In : Parasites & Vectors.11, 1, 22 p., 617

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Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni

Padalino, G., Ferla, S., Brancale, A., Chalmers, I. & Hoffmann, K. 2018 In : International Journal for Parasitology: Drugs and Drug Resistance.

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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Théry et al. 2018 In : Journal of Extracellular Vesicles

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An Abeis procera – Derived tetracyclic triterpene containing a steroid-like core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni

Whiteland, H., Chakroborty, A., Forde-Thomas, J., Crusco, A., Cookson, A., Hollinshead, J., Fenn, C., Bartholomew, B., Holdsworth, P. A., Fisher, M., Nash, R. J. & Hoffmann, K. 2018 In : International Journal for Parasitology: Drugs and Drug Resistance

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Antibody Responses to Schistosoma mansoni Schistosomula Antigens

Egesa M., Lubyayi L, Jones F, van Diepen A, Chalmers I, Tukahebwa E, Bagaya B, Hokke C, Hoffmann K, Dunne D, Elliott A,8, Yazdanbakhsh M, Wilson S, Cose S.  21 Sep 2018 In : Parasite Immunology. e12591.

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S. mansoni Schistosomula Antigens Induce Th1/Proinflammatory Cytokine Responses

Egesa, M., Lubyayi, L., Tukahebwa, E. M., Bagaya, B. S., Chalmers, I., Wilson, S., Hokke, C. H., Hoffmann, K., Dunne, D. W., Yazdanbakhsh, M., Labuda, L. A. & Cose, S. 21 Sep 2018 In : Parasite Immunology. e12592

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The anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulation transcription, translation and stem cell activities

Geyer, K., Munshi, S. E., Vickers, M., Squance, M., Wilkinson, T., Berrar, D., Chaparro, C., Swain, M. & Hoffmann, K. 01 Aug 2018 In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 2, p. 213-222 10 p.

Article DOI: 10.1016/j.ijpddr.2018.03.006

Methyl-CpG-binding (SmMBD2/3) and chromobox (SmCBX) proteins are required for neoblast proliferation and oviposition in the parasitic blood fluke Schistosoma mansoni

Geyer, K., Munshi, S. E., Whiteland, H., Fernandez-Fuentes, N., Phillips, D. & Hoffmann, K. 28 Jun 2018 In : PLOS Pathogens.

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Detection of Galba truncatula, Fasciola hepatica and Calicophoron daubneyi environmental DNA within water sources on pasture land, a future tool for fluke control?

Jones, R., Brophy, P., Davis, C., Davies, T., Emberson, H., Rees Stevens, P. & Williams, H. 08 Jun 2018 In : Parasites & Vectors. 11, 342

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Purification of native Sigma Class Glutathione Transferase from Fasciola hepatica

Duncan, J., Cutress, D., Morphew, R. & Brophy, P. 01 Jun 2018 In : Molecular and Biochemical Parasitology. 222, p. 45-50 6 p.

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Design, synthesis and anthelmintic activity of 7-keto-sempervirol analogues

Crusco, A., Bordoni, C., Chakroborty, A., Whatley, K. C. L., Whiteland, H., Westwell, A. D. & Hoffmann, K. 25 May 2018 In : European Journal of Medicinal Chemistry. 152, p. 87-100

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Histone methylation changes are required for life cycle progression in the human parasite Schistosoma mansoni

Roquis, D., Taudt, A., Geyer, K., Padalino, G., Hoffmann, K., Holroyd, N., Berriman, M., Allaga, B., Chaparro, C., Grunau, C. & de Carvalho Augusto, R. 21 May 2018 In : PLOS Pathogens. 14, 5, 26 p., 1007066

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Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles

Egesa, M., Hoffmann, K., Hokke, C. H., Yazdanbakhsh, M. & Cose, S. 01 Dec 2017 In : Trends in Parasitology. 1671, 4 p.

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Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense

Nur-e-Alam, M, Yousaf, M, Ahmed, S, Al-Sheddi, ES, Shah, I, Fazakerley, D, Bari, A, Ghabbour, HA, Threadgill, MD, Whatley, K, Hoffmann, K & Al-Rehaily, AJ 2017, ‘ Journal of Natural Products.

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Saprotrophic proteomes of biotypes of the witches’ broom pathogen Moniliophthora perniciosa

Pierre, S, Griffith, G, Morphew, R, Mur, L & Scott, I 2017, Fungal Biology. Article

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The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni

Geyer, K, Niazi, U, Duval, D, Cosseau, C, Tomlinson, C, Chalmers, I, Swain, M, Cutress, D, Bickham-Wright, U, Munshi, SE, Grunau, C, Yoshino, TP & Hoffmann, K 2017, PLoS Neglected Tropical Diseases, vol 11, no. 5, e0005246.

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Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Adema, CM, Hillier, LW, Jones, CS, Loker, ES, Knight, M, Minx, P, Oliveira, G, Raghavan, N, Shedlock, A, do Amaral, LR, Arican-Goktas, HD, Assis, JG, Baba, EH, Baron, OL, Bayne, CJ, Bickham-Wright, U, Biggar, KK, Blouin, M, Bonning, BC, Botka, C, Bridger, JM, Buckley, KM, Buddenborg, SK, Lima Caldeira, R, Carleton, J, Carvalho, OS, Castillo, MG, Chalmers, IW, Christensens, M, Clifton, S, Cosseau, C, Coustau, C, Cripps, RM, Cuesta-Astroz, Y, Cummins, SF, Di Stephano, L, Dinguirard, N, Duval, D, Emrich, S, Feschotte, C, Feyereisen, R, Fitzgerald, P, Fronick, C, Fulton, L, Galinier, R, Gava, SG, Geusz, M, Geyer, KK, Giraldo-Calderón, GI, de Souza Gomes, M, Gordy, MA, Gourbal, B, Grunau, C, Hanington, PC, Hoffmann, KF, Hughes, D, Humphries, J, Jackson, DJ, Jannotti-Passos, LK, De Jesus Jeremias, W, Jobling, S, Kamel, B, Kapusta, A, Kaur, S, Koene, JM, Kohn, AB, Lawson, D, Lawton, SP, Liang, D, Limpanont, Y, Liu, S, Lockyer, AE, Lovato, TL, Ludolf, F, Magrini, V, Mcmanus, DP, Medina, M, Misra, M, Mitta, G, Mkoji, GM, Montague, MJ, Montelongo, C, Moroz, LL, Munoz-Torres, MC, Niazi, U, Noble, LR, Oliveira, FS, Pais, FS, Papenfuss, AT, Peace, R, Pena, JJ, Pila, EA, Quelais, T, Raney, BJ, Rast, JP, Rollinson, D, Rosse, IC, Rotgans, B, Routledge, EJ, Ryan, KM, Scholte, LLS, Storey, KB, Swain, M, Tennessen, JA, Tomlinson, C, Trujillo, DL, Volpi, EV, Walker, AJ, Wang, T, Wannaporn, I, Warren, WC, Wu, X-J, Yoshino, TP, Yusuf, M, Zhang, S-M, Zhao, M & Wilson, RK 2017, Nature Communications, vol 8, 15451 (2017), pp. 15451.

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The prevalence and development of digenean parasites within their intermediate snail host, Galba truncatula, in a geographic area where the presence of Calicophoron daubneyi has recently been confirmed

Jones, R, Williams, H, Dalesman, S, Sinmidele, A, Thomas, RK & Brophy, P 2017, Veterinary Parasitology.

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Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial 

Garcia-Perez, I, Posma, JM, Gibson, R, Chambers, ES, Hanson, TH, Vestergaard, H, Hansen, T, Beckmann, M, Pedersen, O, Elliott, P, Stamler, J, Nicholson, JK, Draper, J, Mathers, JC, Holmes, E & Frost, G 2017, Lancet Diabetes and Endocrinology, vol 5, no. 3, pp. 184-195. Article DOI: 10.1016/S2213-8587(16)30419-3


(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

Cosseau, C, Wolkenhauer, O, Padalino, G, Geyer, K, Hoffmann, K & Grunau, C 2016, ‘ Trends in Parasitology.

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Upgrading short read animal genome assemblies to chromosome level using comparative genomics and a universal probe set

Damas, J, O’connor, R, Farré, M, Lenis, V, Martell, H, Mandawala, A, Fowler, K, Joseph, S, Swain, M, Griffin, D & Larkin, DM 2016, Genome Research, vol 27, pp. 875-884.

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Challenges and priorities for modelling livestock health and pathogens in the context of climate change

Özkan, Ş, Vitali, A, Lacetera, N, Amon, B, Bannink, A, Bartley, DJ, Blanco-penedo, I, De Haas, Y, Dufrasne, I, Elliott, J, Eory, V, Fox, NJ, Garnsworthy, PC, Gengler, N, Hammami, H, Kyriazakis, I, Leclère, D, Lessire, F, Macleod, M, Robinson, TP, Ruete, A, Sandars, DL, Shrestha, S, Stott, AW, Twardy, S, Vanrobays, M-L, Ahmadi, BV, Weindl, I, Wheelhouse, N, Williams, AG, Williams, HW, Wilson, AJ, Østergaard, S & Kipling, RP 2016, Environmental Research, vol 151, pp. 130-144.

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MetaPred2CS: a sequence-based meta-predictor for protein-protein interactions of prokaryotic two-component system proteins

Kara, A, Vickers, M, Swain, M, Whitworth, D & Fernandez-Fuentes, N 2016, Bioinformatics, vol 32, no. 21, pp. 3339-3341.

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Rumen fluke Calicophoron daubneyi on Welsh farms: Prevalence, risk factors, and observations on co-infection with Fasciola hepatica

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MultiGrain/MAPPER: A distributed multiscale computing approach to modeling and simulating gene regulation networks

Mizeranschi, AE, Swain, MT, Scona, R, Fazilleau, Q, Bosak, B, Piontek, T, Kopta, P, Thompson, P & Dubitzky, W 2016 Future Generation Computer Systems, vol 63, pp. 1-14.

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Antelope Diseases – the Good, the Bad and the Ugly. in Antelope Conservation: From Diagnosis to Action.

Kock, R, Chardonnet, P & Risley, C 2016, Conservation Science and Practice, Wiley, pp. 108-135.

Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola Species

Morphew, R, Wilkinson, T, MacKintosh, N, Jahndel, V, Paterson, S, McVeigh, P, Abbas Abidi, SM, Saifullah, K, Raman, M, Ravikumar , G, LaCourse, EJ, Maule, AG & Brophy, P 2016, Journal of Proteome Research, vol 15, no. 9, pp. 3308-3321.

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DISMISS: MeDIP-seq: High-throughput sequencing

Niazi, U, Geyer, K, Vickers, M, Hoffmann, K & Swain, M, , 2016, Software, OMICtools.

DISMISS: detection of stranded methylation in MeDIP-Seq data

Niazi, U, Geyer, KK, Vickers, MJ, Hoffmann, K & Swain, M 2016, BMC Bioinformatics, vol 17, 295.

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InteractoMIX: a suite of computational tools to exploit interactomes in biological and clinical research

Poglayen, D, Marín-López, MA, Bonet, J, Fornes, O, Garcia-Garcia, J, Planas-Iglesias, J, Segura, J, Oliva, B & Fernandez-Fuentes, N 2016, Biochemical Society Transactions, vol 44, no. 3, pp. 917-924. Article DOI: 10.1042/BST20150001

The effects of PPO activity on the proteome of ingested red clover and implications for improving the nutrition of grazing cattle 

Hart, E, Onime, LA, Davies, T, Morphew, R & Kingston-Smith, A 2016, Journal of Proteomics, vol 141, pp. 67-76.

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Calmodulin disruption impacts growth and motility in juvenile liver fluke

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